By Nicolle Sitte, Thomas von Zglinicki (auth.), Thomas von Zglinicki (eds.)
During the final forty years, the research of the organic foundation of getting older has advanced vastly, and it has now develop into an self reliant and decent box of analysis and learn. the fundamental reason behind getting older is molecular harm that slowly overwhelms mobile and organismic safeguard, fix and upkeep platforms. lately, a wealth of hugely subtle examine has reworked this concept from a reputable speculation not just to a huge thought, yet primarily to accredited wisdom. getting older on the Molecular point examines the most important parts during this transformation.
Bringing jointly contributions from a global workforce of authors, this quantity may be of curiosity to graduates and postgraduates within the fields of drugs and nursing, researchers of other facets of biogerontology and people within the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.
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Additional resources for Aging at the Molecular Level
The final step of the cross-linking process is the formation of a water insoluble material called age-pigment or lipofuscin (see section on "Accumulation and degradation of oxidized proteins during aging"), which can not be degraded and accumulates in senescent cells (see Chapter 15, this volume). Mechanisms of oxidative modifications of protein structures Oxidation of proteins normally is caused by free radicals, and this process, from a chemical thermodynamics standpoint, is an exothermic event.
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