Aging Research - Methodological Issues by Carmen García-Peña, Luis Miguel Gutiérrez-Robledo, Mario

By Carmen García-Peña, Luis Miguel Gutiérrez-Robledo, Mario Ulises Pérez-Zepeda

This publication stories classical epidemiological and medical examine experiences, with a spotlight on getting older. Chapters conceal methodological subject matters just like the clinical strategy, ethics, and the results of definite exclusion standards and the paintings encompasses a examine scientific recommendations like multi morbidity, frailty and performance. The authors display the problems and demanding situations for researchers of age and getting older, and likewise examine the interpretation of clinical wisdom, from easy to medical and from medical to public regulations of social and health and wellbeing care.

The specialise in getting older is what supplies this booklet its worthwhile standpoint on study method. All authors have significant event in getting older, geriatrics or gerontology and every bankruptcy contains either a theoretical framework and functional examples of reports in getting older. Readers will become aware of examine designs which are reviewed for simple constitution, major flaws and benefits and are analyzed for particular stipulations and variables relating to aging.

This textual content is fitted to either future health care execs taking good care of older adults and researchers who're new to investigate in getting older. it truly is correct around the disciplines, together with drugs, psychology, social sciences and dentistry and it helps studying with graphs and figures.

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Exp Gerontol 46(5):340–344. 005 39. Zhou S, Mackay T, Anholt RR (2014) Transcriptional and epigenetic responses to mating and aging in Drosophila melanogaster. BMC Genomics 15:927. 1186/1471-2164-15-927 40. Specks J, Nieto-Soler F, Lopez-Contreras AJ (2015) Modeling the study of DNA damage responses in mice. In: Eferl R, Casanova E (eds) Mouse models of cancer. Methods and protocols. Methods in molecular biology. Springer Protocols, Humana Press, London, pp 413–437 41. Gorbunova V, Bozzella MJ, Seluanov A (2008) Rodents for comparative aging studies: from mice to beavers.

Some species (of the order Cyprinodontiformes) and zebrafish (Danio rerio), guppie fish (Poecilia reticulata) and killifish (genus Nothobranchius) have been considered study models from the biogerontological point of view [20, 48–51] (b) Bees have been used as model organisms in relation to vertebrates, since they experience biochemical changes with aging, among which include, reduced proteolytic and antioxidant enzymes, in addition to increased levels of methylation in aging [52, 53] recent study in Western bees (Apis mellifera) showed that exposure to caffeine in a dose-dependent manner (safe dose of 5 mg/ml), delays the biochemical changes associated with aging and slowing the process of global DNA methylation [53]; (c) Other models like domestic dogs [54], cats and horses [55], have also been used to study more specific conditions, such as the study of degenerative macular disease in beagles.

0000000000000817 43. Austad SN (2011) Candidate bird species for use in aging research. ILAR J 52(1):89–96 44. Selman C, Withers DJ (2011) Mammalian models of extended healthy lifespan. Philos Trans R Soc Lond B Biol Sci 366(1561):99–107. 0243 45. Ricklefs RE (2010) Insights from comparative analyses of aging in birds and mammals. Aging Cell 9(2):273–284. x 46. Clutton-Brock T, Sheldon BC (2010) Individuals and populations: the role of long-term, individual-based studies of animals in ecology and evolutionary biology.

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