By Paul Willner (auth.), Alan A. Boulton, Glen B. Baker, Mathew T. Martin-Iverson (eds.)
The Animal types in Psychiatry volumes are loosely geared up by means of topic. the 1st quantity includes a variety of chapters interested by schizophrenia, psyc- ses, neuroleptic-induced tardive dyskinesias, and different d- orders that can contain dopamine, equivalent to recognition deficit sickness and mania. the second one quantity bargains with affective and nervousness problems, but in addition contains chapters on topics no longer simply categorized as both psychotic, or affective, or an- ety-related, corresponding to aggression, psychological retardation, and reminiscence issues. 4 chapters on animal types of schizophrenia or psychoses are incorporated within the current v- ume due to the value of those issues in p- chiatry. Likewise, 3 chapters within the next quantity care for melancholy. the 1st of the 2 volumes starts off with an introd- tion by way of Paul Willner reviewing the factors for assessing the validity of animal types in psychiatry. He has written - tensively in this topic, and his thorough description of the problems of varied sorts of validity presents a framework during which to guage the next chapters. As should be obvious, the remainder chapters in either volumes will refer usually to those matters. the second one bankruptcy, via Melvin Lyon, describes plenty of assorted methods which have been p- posed as capability animal versions of schizophrenia. this can be a departure from the standard structure, along with precise - scriptions of particular models.
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Extra resources for Animal Models in Psychiatry, I
An attempt will also be made to indicate promising areas for future research. Since the dopamine (DA) overactivation hypothesis has been the leading theoretical view in schizophrenia research (Carlsson, 1988), much of what follows will consider how well this hypothesis holds. An important characteristic of any model must be that the symptoms produced are ameliorated by neuroleptic drugs, which, in the main, are antidopaminergic in function. , 1990). As a result of these disagreements, and also because of the significant modulating effects on DA systems caused by other neurotransmitters and neuromodulators, it is necessary to consider multiple causative factors in the neurochemistry of schizophrenia.
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