By Vincent J. Cristofalo PhD
This quantity provides a transparent, concise assessment of the present nation of data in regards to the biology of getting older √± serving as either a useful graduate-level textual content and a key reference for practising execs. Over a dozen exceptional members probe the newest advancements in our wisdom of why humans age and the way the method works. those authoritative chapters will not be simply written for biologists √± yet for gerontologists usually. Marks the 10th anniversary of the yearly evaluation of Gerontology and Geriatrics.
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Extra resources for Annual Review of Gerontology and Geriatrics, Volume 10, 1990: Biology of Aging
It is not life-span but rather the mechanism regulating the process of aging that is of interest, however. By any definition of aging, these normal cells in culture undergo aging processes. There is a gradual failure in functional capacity—in this case proliferative capacity—and the cells show changes similar to changes in vivo. Cellular aging under controlled environmental conditions and in the absence of tissue- and cell-type interactions has profound implications for the theories of biological aging.
Cases that are trisomic for other parts of chromosome 21 but diploid for this region produce a chromosomal phenotype, but without the specific stigmata of DS. It appears that the trisomic presence of this limited region allows for nearly full expression of the syndrome. Some of the genes in this subregion could have a major effect on producing the senescent phenotype seen in DS. The development of the brain in particular, as well as other organs, requires a delicate balance between the growth rates of various interacting cell types.
They were unsuccessful. During the course of this work, however, they noticed that a period of rapid and vigorous cellular proliferation was consistently followed by a period of decline in proliferative activity during which the cells acquired characteristics reminiscent of senescent cells in vivo, and the apparent senescence was followed finally by the death of the cultures. Swim and Parker (1957) and perhaps others had made this same observation previously, but Hayflick and Moorhead, with extraordinary insight, recognized the process as senescence in culture.