By B. Müller, Hans-Georg Kräusslich (auth.), Hans-Georg Kräusslich, Ralf Bartenschlager (eds.)
A the most important factor for antiviral remedy is the truth that all antiviral elements speedily opt for for resistance; therefore, tracking and overcoming resistance has develop into a most crucial scientific paradigm of antiviral remedy. This demands wary use of antiviral medicinal drugs and implementation of mix treatments. In parallel, efforts in drug discovery need to be persisted to improve compounds with novel mode-of-action and job opposed to resistant lines. This booklet experiences the present prestige of antiviral remedy, from the roads to improvement of recent compounds to their medical use and price effectiveness. person chapters tackle in additional aspect all to be had drug sessions and description new methods at the moment less than development.
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Additional info for Antiviral Strategies
This pool of pre-existing mutations will also comprise those that by chance confer some degree of resistance to an antiviral drug used for therapy. Since these mutations are often associated with lower viral fitness, that is, lower replication rates compared to wild-type in the absence of the drug, they generally only represent a minor fraction of the viral population before treatment is initiated; however, they will be selected by treatment with drug concentrations insufficient to completely suppress replication of moderately resistant virus.
Therefore, new therapeutic strategies are urgently needed (Manns et al. 2006), including small orally bioavailable molecules as well as combined modalities to prevent or delay the development of drug-resistant HCV. 1 Approaches to Discovery Improved treatment for HCV requires the development of novel agents with unique biological profiles that are effective against a broad range of viral genotypes. While drug or target discovery represents the beginning of the process, multiple studies are required before an antiviral agent becomes a useful, and in particular, safe drug for humans.
1 One at a Time Traditional Synthesis . . . . . . . . . . . . . . . . . . . . 2 Parallel Synthesis . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Combinatorial Chemistry . . . . . . . . . . . . . . . . . . . . . . . . 4 High-Throughput Screening for the Identification of New HCV Leads . . . . . 5 Cell-Based Assays to Predict Toxicity and Resistance Aspects . . . .